Endocrine Abstracts

Introduction: The effects of long-term replacement therapy of primary adrenal insufficiency (PAI) are still a matter of debate. Glucocorticoid (GC) replacement regimens do not completely mimic the endogenous hormonal production and their monitoring is sometimes difficult. Therefore, some patients are exposed to mild GC excess with potential complications, such as hypertension, diabetes, and skeletal fragility. Data on bone mineral density (BMD) in PAI is still scarce and contr...

Introduction: Pseudohypoparathyroidism is a heterogeneous disease characterized by hypocalcemia, hyperphosphatemia and parathyroid hormone resistance. The distinct pseudohypoparathyroidism types are distinguished by physical features, the coexistence of other hormone resistances and genetic defects. Pseudohypoparathyroidism type Ib is more often associated with sporadic cases, unlike others types.Clinical Case: Male, born in France, diagnosed with pseudo...

Introduction: Diabetes is a recognized risk factor for the development of complications in COVID-19 infection, with an increased incidence of ketoacidosis observed in patients admitted to hospital.Case Reports: We present the case of a patient with type 1 DM complicated by diabetic retinopathy and unplanned pregnancy (pregestational Hba1c 9.1%). In follow-up during pregnancy: progression of retinopathy and fetal renal pyeloectasia in morphological ultras...

Introduction: Sheehan Syndrome (SS) is a cause of hypopituitarism resulting from postpartum pituitary infarction. Its frequency is decreasing worldwide, particularly in developed countries due to advances in obstetric care. Case report: A 50-year-old female patient was admitted to the emergency department with complains of progressive pain in the lower hemithorax and abdomen. She also referred constipation, weight gain and asthenia. The initial laborator...

Introduction: Hypopituitarism is a rare entity that can have different aetiologies. Symptoms are usually progressive and non-specific; therefore, many patients are underdiagnosed and untreated. We present a clinical case of a patient presenting septic shock, hyponatremia and central hypothyroidism.Case report: A 46-year-old man was admitted in ICU for septic shock of unknown origin and multiorgan failure. Hormonal profile showed central hypothyroidism, p...

Introduction: The Dandy-Walker complex (DW) comprises a rare intracranial malformation of the posterior fossa and multiple organ anomalies. The association with endocrine pathology is rare - described in isolated cases (Kallman syndrome, primary hypothyroidism (PH) and central precocious puberty). Noonan syndrome (NS) is a genetic disease usually diagnosed at birth, with variable phenotype. Most cases have AD transmission, with the PTPN11 gene mutation responsible for 50%....

Introduction: The prevalence of Transgender individuals seeking gender affirming hormone therapy (GAHT) has been increasing. It is important to closely monitor this therapy in order to minimize the risk of adverse effects.Aim: To evaluate the safety and monitoring of the GAHT in the Portuguese adult transgender populationMethods: Cross-sectional study conducted in March 2021. Data collected through an online questionnaire ...

Background: Post surgery hypocalcemia is the most common sequel of thyroidectomy. An accurate prediction of hypocalcemia in the immediate postoperative period would enable the selection of patients for appropriate treatment and facilitate early discharge. Objective: This study aims to investigate the prevalence of hypocalcemia after thyroidectomy and to identify potential risk factors. Methods: This is a retrospective cohort study ...

A major limitation of nutritional science is the objective assessment of dietary intake in free-living populations. Monitoring individuals’ response to policy recommendations is based on self-reported dietary assessment tools, which are known to have high misreporting rates estimated at 30–88%. We have developed a novel analytical pipeline capable to classify people into consumers of a healthy or unhealthy diet based on urinary metabolic patterns, without relying on ...

High protein diets are highly satiating but hard to maintain. By understanding the mechanisms underlying these effects we may be able to identify new anti-obesity therapies. Protein is broken-down into amino acids in the gut which are detected by a series of nutrient sensors. The calcium sensing receptor (CaSR) is primarily activated by calcium ions, but is positively allosterically modulated by aromatic amino acids, especially L-phenylalanine. Sti...